Early Treatment of Congenital Anophthalmia and Congenital Microphthalmia: What is Congenital Anophthalmia? The absence of one or both eyes. Both the globe and the ocular tissue are missing from the orbit. The absence of the eye causes a small bony orbit, a constricted mucosal socket, short eyelids, reduced palpebral fissure and malar prominence.. What is Congenital Microphthalmia? A developmental disorder …